Many latitude/longitude locations can be visited using global positioning systems (handheld GPS units) regardless of whether or not they have a geocach. Here are some things to keep in mind when planning your trip, especially if you are going to visit off road locations.
Learn how to use your GPS unit before your trip. Find out as much as you can about the area you are going to visit from maps, online sources, government agencies or local residents. Determine how far you will have to travel from the nearest road. Check the weather forecast before you leave and dress appropriately. Temperatures can drop significantly at night, especially in higher elevations. Take more than enough food and water. Other important items include a flashlight, first aid kit, cell phone, extra batteries, sunscreen and a compass. If possible, travel with companions. Tell someone where you are going and when you expect to return.
Do not enter onto private property, including where No tresspassing, Keep out, or Private property is posted unless you have the owner's permission. Don't litter. Leave the area the same way you find it. Leave gates either open or closed, the same way you find them. Obey all laws and restrictions that apply when accessing public lands.
Be smart and be safe
If you plan to go to a location without a Geocache you may be the first person to visit the area. Some locations are just plain inaccessible. They may be located in difficult terrain. You may find your course blocked by hazards such as rivers or steep ravines. Use your judgement. If you can't find a reasonably safe route within a reasonable amount of time, choose another place to visit.
Visit the Geographic Midpoint Calculator which allows you to calculate the geographic midpoint for two or more places. Fast access to a database of millions of world cities and towns. You can see the location of the midpoint on a Google map.